Blood film after myelosuppressive chemotherapy or under G-CSF treatment

Neutrophilic abnormalities that typically occur in bacterial infections, such as coarse granules, vacuoles and Döhle bodies, are described as toxic. However, these abnormalities can also be observed in the recovery stage after myelosuppressive chemotherapy. Stimulation with granulocyte-colony stimulating factor (G-CSF) can  amplify these abnormalities.


Clinical picture:
Dependent on cause.



Neutrophils show toxic abnormalities (coarse granules, vacuoles and Döhle bodies). In addition, a shift to the left is usually present and in infections, a leukocytosis is present.