In chronic kidney failure, hypoproliferative anemia occurs regularly (reticulocyte count relatively or absolutely decreased). Renal anemia is normochromic and normocytic. It can be severe with hemoglobin concentrations below 60 g/L . The cause of this anemia is multifactorial, however, the major cause is decreased erythropoietin production by the damaged kidney. Additionally, erythrocyte life span is reduced.
Today, anemia of renal disease is almost exclusively observed in the diagnosis of chronic kidney failure. Anemia of renal disease can be eliminated to a large extent by administering recombinant erythropoietin. Especially in patients undergoing dialysis, iron deficiency is often also present. Therefore, iron must also been given.
Anemia of renal disease is a normochromic, normocytic anemia. The only special morphological feature is the frequent occurrence of acanthocytes. The reticulocyte count is diminished. Serum erythropoietin can be measured and is clearly reduced.