Basophilic stippling


In basophilic stippling, fine, basophilic dots are distributed over the entire erythrocyte. Like polychromasia, this is an indication of RNA remnants that lend a basophilic color to the cell.


Basophilic stippling occurs with increased erythropoiesis as is typical in hemolysis or after replacement therapy in nutritional deficiency (iron, vitamin B12). A coarse basophilic stippling is observed in lead poisoning.