The leukoerythroblastic blood picture is, as the name implies, characterized by the presence of immature forms of red and white cells in the peripheral blood. Normoblasts as well as myeloblasts, promyelocytes, myelocytes and metamyelocytes may be present.
There is no unique clinical picture, but rather leukoerythroblastic is a descriptive term. The leukoerythroblastic blood film results from infiltration and replacement of bone marrow cells through infection or metastasis as well as from myeloproliferative and lymphoproliferative neoplasms. It may also be seen with severe bleeding and acute hemolysis (increased cell production).
The leukocyte count may be increased, normal, or decreased. The presence of normoblasts and immature myeloid cells is common. Anisocytosis and poikilocytosis of the erythrocytes usually results. Polychromasia suggests increased erythropoiesis.